Transcript profiles of juvenile female brown trout exposed to glyphosate and Roundup herbicides.

ABSTRACT: This study aimed to investigate the hepatic transcriptional response of brown trout to glyphosate, and its formulated product, Roundup. We exposed juvenile female brown trout to three concentrations of glyphosate (0.01, 0.5 and 10 mg/L) and Roundup (0.01, 0.5 and 10 mg/L glyphosate acid equivalent) for 14 days and sequenced the hepatic transcriptome of 6 individual females per treatment group in order to determine the global mechanisms of toxicity of this widely used herbicide. We assembled the brown trout transcriptome using an optimised de novo approach, and subsequent differential expression analysis identified a total of 1020 differentially-regulated transcripts across all treatments. Differentially-expressed transcripts included those encoding components of the antioxidant system, a n

ORGANISM(S): Salmo trutta

SUBMITTER: Tamsyn Uren Webster 

PROVIDER: E-GEOD-56855 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress