Progression to Latent Infection Following Exposure to Mtb

ABSTRACT: These results were obtained in a controlled longitudinal experiment in which a group of rhesus macaques were exposed to a low dose of Mtb to study their progression to latent infection or active disease. Subsets of the animals were euthanized at scheduled time points, and granulomas taken from their lungs were assayed for gene expression. The clinical profiles associated with the animals following Mtb exposure revealed considerable variability, and we developed models for the disease trajectory for each subject using a Bayesian hierarchical B-spline approach. Disease severity estimates were derived from these fitted curves and included as covariates in linear models to identify genes significantly associated with disease progression. Our results demonstrate that the incorporation of clinic

ORGANISM(S): Macaca mulatta

SUBMITTER: Deepak Kaushal 

PROVIDER: E-GEOD-56919 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress