Blood gene expression reveals reduced circadian rhythmicity in individuals resistant to sleep deprivation

ABSTRACT: To address whether changes in gene expression in blood cells with sleep loss are different in individuals resistant and sensitive to sleep deprivation (SD). Blood draws every 4 hours during a 3-day study: 24-hour normal baseline, 38 hours of continuous wakefulness and subsequent recovery sleep, for a total of 19 time-points per subject, with every 2-hr psychomotor vigilance test (PVT) assessment when awake. Fourteen subjects who were previously identified as behaviourally resistant (n=7) or sensitive (n=7) to SD by PVT. Intervention consisted of 38 hours continuous wakefulness. We found 4,481 unique genes with a significant 24-hour diurnal rhythm during a normal sleep-wake cycle in blood (false discovery rate [FDR] <5%). Biological pathways were enriched for biosynthetic processes during

ORGANISM(S): Homo sapiens

SUBMITTER: Keith Shockley 

PROVIDER: E-GEOD-56931 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress