Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Regulatory consequences of TARBP2 knock-down in MDA-LM2-shDicer cell-line

ABSTRACT: siRNA-mediated knock-down followed by transcriptomic profiling revealed that silencing of TARBP2 resulted in a significant up-regulation of sRSE-carrying transcripts. Two independent siRNAs were used to knock down TARBP2 in metastatic MDA-LM2 shDicer cells. The cells were then subjected to transcripome profiling in comparison to mock-transfected cells.

ORGANISM(S): Homo sapiens

SUBMITTER: Hani Goodarzi 

PROVIDER: E-GEOD-56950 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Metastasis-suppressor transcript destabilization through TARBP2 binding of mRNA hairpins.

Goodarzi Hani H   Zhang Steven S   Buss Colin G CG   Fish Lisa L   Tavazoie Saeed S   Tavazoie Sohail F SF  

Nature 20140709 7517

Aberrant regulation of RNA stability has an important role in many disease states. Deregulated post-transcriptional modulation, such as that governed by microRNAs targeting linear sequence elements in messenger RNAs, has been implicated in the progression of many cancer types. A defining feature of RNA is its ability to fold into structures. However, the roles of structural mRNA elements in cancer progression remain unexplored. Here we performed an unbiased search for post-transcriptional modula  ...[more]

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