A luteal phase deficiency model in normal women: structural and functional responses to varying concentrations of progesterone

ABSTRACT: Progesterone (P) action is essential for embryo implantation, but the P concentration required for normal receptivity remains unclear. We use an in vivo model in normal women that abolishes detectable endogenous P production, allowing experimental provision of P. Endometrial samples on the 10th day of varying doses of P exposure are compared structurally and functionally with each other and with mid-secretory endometrium of natural cycles, using histological and microarray analysis. At 2.5mg/day of P, a delayed appearance of morphological features is seen. Higher sub-physiological levels of P result in normal morphology, but aberrant gene expression. These studies prove that low P levels can result in histological delay, consistent with clinical expectations. However, P levels required for

ORGANISM(S): Homo sapiens

SUBMITTER: Ricardo Savaris 

PROVIDER: E-GEOD-56980 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress