Cpeb4-mediated Translational Regulatory Circuitry Controls Terminal Erythroid Differentiation

ABSTRACT: Erythropoiesis is essential to mammals and is regulated at multiple steps by both extracellular and intracellular factors. Many transcriptional regulatory networks in erythroid differentiation have been well characterized. However, our understanding of post-transcriptional regulatory circuitries in this developmental process is still limited. Using genomic approaches, we identified a sequence-specific RNA-binding protein, Cpeb4, which is dramatically induced in terminal erythroid differentiation (TED) by two erythroid important transcription factors, Gata1/Tal1. Cpeb4 belongs to the cytoplasmic polyadenylation element binding (CPEB) protein family that regulates translation of target mRNAs in early embryonic development, neuronal synapse, and cancer. Using primary mouse fetal liver erythro

ORGANISM(S): Mus musculus

SUBMITTER: Wenqian Hu 

PROVIDER: E-GEOD-57004 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress