Genome-wide analysis of histone modifications in human endometrial stromal cells [ChIP-Seq]

ABSTRACT: Dramatic changes of gene expressions are known to occur in human endometrial stromal cells (ESC) during decidualization. The changes in gene expression are associated with changes of chromatin structure, which are regulated by epigenetic mechanisms such as histone modifications. Here, we investigated genome-wide changes in histone modifications and mRNA expressions associated with decidualization in human ESC using chromatin immunoprecipitation (ChIP) combined with next-generation sequencing. ESC were incubated with estradiol and medroxyprogesterone acetate for 14 days to induce decidualization. The ChIP-sequence data showed that induction of decidualization increased H3K27ac and H3K4me3 signals in many genomic regions but decreased in only a few regions. Most (80%) of the H3K27ac-inc

ORGANISM(S): Homo sapiens

SUBMITTER: Isao Tamura 

PROVIDER: E-GEOD-57007 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress