Systems Biology Analysis of Tenofovir 1% Gel in a Phase I Rectal Microbicide Trial

ABSTRACT: In MTN-007, a phase 1, randomized, double-blinded rectal microbicide trial, we used systems genomics/proteomics to determine the effect of tenofovir 1% gel, nonoxynol-9 2% gel, placebo gel or no treatment on rectal biopsies taken at baseline, after one application or after seven daily applications (15 subjects/arm). Experiments were repeated using primary vaginal epithelial cells from four healthy women. 192 Arrays (8 donors per treatment group, 2 biopsy sites per donor (9cm and 15 cm), biopsies taken at baseline, after a single application, and after 7 daily applications)

ORGANISM(S): Homo sapiens

SUBMITTER: Lamar Fleming 

PROVIDER: E-GEOD-57025 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress