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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Gene based expression changes in glioblastoma cells after downregulation of MPS1 kinase

ABSTRACT: Gene expression changes were analyzed in U251 GBM cells after downregulation of MPS1 by RNA interference technology at different time points Microarray analysis was used to compare the mRNA expression profile of siMPS1 silenced U251 cells compared to siNegative (siNeg) and untransfected (Control) cells at 6, 24 and 48 hours post tranfection

ORGANISM(S): Homo sapiens

SUBMITTER: Uma Shankavaram

PROVIDER: E-GEOD-57091 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Targeting MPS1 Enhances Radiosensitization of Human Glioblastoma by Modulating DNA Repair Proteins.

Maachani Uday Bhanu UB Kramp Tamalee T Hanson Ryan R Zhao Shuping S Celiku Orieta O Shankavaram Uma U Colombo Riccardo R Caplen Natasha J NJ Camphausen Kevin K Tandle Anita A

Molecular cancer research : MCR 20150226 5

<h4>Unlabelled</h4>To ensure faithful chromosome segregation, cells use the spindle assembly checkpoint (SAC), which can be activated in aneuploid cancer cells. Targeting the components of SAC machinery required for the growth of aneuploid cells may offer a cancer cell-specific therapeutic approach. In this study, the effects of inhibiting Monopolar spindle 1, MPS1 (TTK), an essential SAC kinase, on the radiosensitization of glioblastoma (GBM) cells were analyzed. Clonogenic survival was used to ...[more]

PMID: 25722303

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