DNA-damage induced differentiation of leukemic cells as an anti-cancer barrier

ABSTRACT: Here we show that the histone methyltransferase MLL4 (Kmt2d) is required for stem cell activity and an aggressive form of acute myeloid leukemia (AML) harboring the MLL-AF9 oncogene. MLL4 exerts its function by regulating transcriptional programs associated with the anti-oxidant response. The role of Mll4 (Kmt2d) in regulating the transcriptome of primary and transformed hematopoietic stem cells was studied.

ORGANISM(S): Mus musculus

SUBMITTER: Robert Faryabi 

PROVIDER: E-GEOD-57147 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress