Transcription profiling of mouse cystic fibrosis model Cftr knockouts ileum were analysed to investigate intestinal phenotypes

ABSTRACT: Cystic fibrosis transmembrane conductance regulator (Cftr) knockout mice present the clinical features of low body weight and intestinal disease permitting an assessment of the interrelatedness of these phenotypes in a controlled environment. To identify intestinal alterations which affect body weight in CF mice the histological phenotypes of crypt-villus axis height, goblet cell hyperplasia, and mast cell infiltrate were measured, cardiac blood samples assessed, and gene expression profiling of the ileum was completed for 12 week old (C57BL/6xBALB) F2 Cftrtm1UNC and non-CF mice presenting a range of body weight. Crypt-villus axis height decreased with increasing weight in CF, but not control, mice. Goblet cell hyperplasia and mast cell infiltration in the submucosa and muscularis exter

ORGANISM(S): Mus musculus

SUBMITTER: Christina Kathleen Haston 

PROVIDER: E-GEOD-5715 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress