Stress response of Salmonella Typhimurium to acidified nitrite

ABSTRACT: The antimicrobial action of the curing agent NaNO2, which is added as a preservative to raw meat products, depends on its conversion to nitric oxide and other reactive nitrogen species under acidic conditions. In this study, we applied RNA-sequencing to analyze the acidified NaNO2 shock and adaptive response of Salmonella Typhimurium, a frequent contaminant in raw meat. Upon a 10 minute exposure to 150 mg/l NaNO2 in LB pH 5.5 acidified with lactic acid, genes involved in nitrosative stress protection together with several other stress related genes were induced. To the contrary, genes involved in translation, transcription, replication and motility were down-regulated. Induction of stress tolerance and reduction of cell proliferation obviously promote survival under harsh acidified NaNO2 s

ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium

SUBMITTER: Stefanie MM-CM-<ller-Herbst 

PROVIDER: E-GEOD-57238 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress