Genomic analysis of low-grade serous ovarian carcinomas [IL610Q]

ABSTRACT: Low-grade serous ovarian carcinomas are typically Ras-pathway mutated, TP53 wild-type, have limited chromosomal aberration, and are frequently associated with borderline tumors. By contrast, high-grade serous ovarian carcinoma lack Ras-pathway mutations, are invariably TP53 mutated, show widespread genomic change, and are commonly BRCA-pathway disrupted. We sought to identify differences in genomic copy number changes between co-existing borderline and invasive components of serous carcinoma. Paired co-existing borderline and invasive tumor components of ovarian serous carcinoma were sampled and profiled from tumors from 7 patients

ORGANISM(S): Homo sapiens

SUBMITTER: Dariush Etemadmoghadam 

PROVIDER: E-GEOD-57279 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress