Microarray study of the Sex Inducer Proteins in Cryptococcus neoformans var. neoformans (JEC20/21)

ABSTRACT: To identify genes regulated by the homeodomain transcription factors Sxi1M-NM-1 and Sxi2a (Sex Inducer 1M-NM-1 and 2a) in Cryptococcus neoformans, we carried out a whole-genome expression experiment. We performed two independent whole-genome microarray experiments comparing transcript levels in cells that either possessed or were lacking the Sxi proteins. In the first experiment we compared the expression profile of a haploid sxi1M-NM-1M-NM-^T strain to that of a haploid strain expressing both SXI1M-NM-1 and an inducible copy of SXI2a (Sxi +). In the second experiment, we compared the expression profile of a wild type cross (JEC20 x JEC21) to the expression profile of a cross whose mating partners did not possess either of the transcription factors (sxi2aM-bM-^HM-^F x sxi1M-NM-1M-bM-^HM-^F

ORGANISM(S): Cryptococcus neoformans var. neoformans

SUBMITTER: Christina Hull 

PROVIDER: E-GEOD-57287 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress