Regulatory and evolutionary footprints of messenger RNA secondary structure in primate transcriptomes

ABSTRACT: Messenger RNA secondary structure is critical to all aspects of post-transcriptional regulation. However, the global regulatory and evolutionary significance of mRNA secondary structure remains largely illusive. Here, we describe a transcriptome-wide analysis of RNA secondary structure in humans and two non-human primates, based on a high-throughput, nuclease-mediated, structure mapping approach. Using this methodology, we uncover global patterns of mRNA secondary structure, which we find to be conserved through primate evolution. We provide evidence for secondary structure-based regulatory pathways, which impact on gene expression through associations with translational machinery and RNA-binding proteins, including components of the microprocessor complex. Our results lend support to an u

ORGANISM(S): Homo sapiens

SUBMITTER: Qi Zheng 

PROVIDER: E-GEOD-57295 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress