High resolution Hi-C analysis in S. pombe reveals fundamental elements of genome architecture (NGS)

ABSTRACT: Eukaryotic genomes are folded into a hierarchy of three-dimensional structures that impact nuclear functions, including transcription, replication, and repair1-3. Studies in Drosophila and mammals have revealed megabase-sized topologically associated domains (TADs) within chromosomes, which in turn are spatially restricted within the nucleus4-8. However, little is known about local physical constraints that drive higher-order folding of chromosomes. Here we performed Hi-C analysis of the fission yeast Schizosaccharomyces pombe to explore genome organization at high resolution. S. pombe comprises a small genome ideal for examining structural features of chromatin folding, and contains fundamental components present in higher eukaryotes. Large domains of heterochromatin coat centromeres and

ORGANISM(S): Schizosaccharomyces pombe

SUBMITTER: Shiv Grewal 

PROVIDER: E-GEOD-57316 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress