ChIP-chip from human fetal brain with H3K27Ac and H3K4Me1

ABSTRACT: Enhancers can regulate the transcription of genes over long genomic distances. This is thought to lead to selection against genomic rearrangements within such regions that may disrupt this functional linkage. We tested this concept experimentally using the human X chromosome. We describe a scoring method to identify evolutionary maintenance of linkage between conserved non-coding elements and neighbouring genes. Chromatin marks associated with enhancer function are strongly correlated with the linkage score. We tested more than 1,000 putative enhancers by transgenesis assays in zebrafish to ascertain the identity of the target gene, with a focus on genes involved in X-linked intellectual disabilities (ID). The majority of active enhancers drive a transgenic expression in a pattern consiste

ORGANISM(S): Homo sapiens

SUBMITTER: Chandr Chilamakuri 

PROVIDER: E-GEOD-57354 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress