The chromatin modifier CHD8 targets autism risk genes during human neurodevelopmentM-BM-

ABSTRACT: Whole-exome sequencing studies have implicated chromatin modifiers and transcriptional regulators in autism spectrum disorder (ASD) through the identification of de novo loss of function mutations in affected individuals. Many of these genes are co-expressed in mid-fetal human cortex, suggesting ASD risk genes converge in regulatory networks that are perturbed in ASD during neurodevelopment. To elucidate such networks we mapped promoters and enhancers bound by the chromodomain helicase CHD8, which is strongly enriched in ASD-associated de novo loss of function mutations, using ChIP-seq in mid-fetal human brain, human neural stem cells (hNSCs), and embryonic mouse cortex. We find that CHD8 targets are strongly enriched for ASD risk genes that converge in ASD-associated co-expression network

ORGANISM(S): Mus musculus

SUBMITTER: Justin Cotney 

PROVIDER: E-GEOD-57369 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress