Insights into the proliferation and invasiveness of breast cancer from genome-wide profiling of estrogen receptor beta 2

ABSTRACT: The human ERβ variant, ERβ2, is expressed at higher levels than ERβ1 in many breast cancer cell lines and breast tumours and increasing evidence supports the hypothesis that ERβ2, in contrast to ERβ1, is associated with aggressive phenotypes of various cancers. We identified a breast cancer cell line that expresses endogenous ERβ2, but not ERα or ERβ1, allowing studies of ERβ2 in the absence of other ER isoforms. Importantly, we show that knockdown of endogenous ERβ2 inhibited cell proliferation and cell invasion. To gain insights into the molecular mechanism responsible for these cellular phenotypes, we assayed ERβ2 dependent global gene expression profiles. A total of 263 genes were identified as potentially ERβ2-upregulated genes and 662 as ERβ2-downregulated genes. ERβ2-regulated gene

ORGANISM(S): Homo sapiens

SUBMITTER: Li Xu 

PROVIDER: E-GEOD-57379 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress