Gene expression of CD14+ cells from RA, PsA and PsO patients with Infliximab treatment

ABSTRACT: objection: The immune inflammatory disorders rheumatoid arthritis (RA), psoriatic arthritis (PsA) and psoriasis (Ps) share common pathologic features and show responsiveness to anti-tumor necrosis factor (TNF) agents yet they are phenotypically distinct. The aim of this study was to examine if anti-TNF therapy is associated with divergent gene expression profiles in circulating cells and target tissues of patients with these diseases Method: Peripheral blood CD14+ and CD14- cells were isolated from 9 RA, 12 PsA and 10 Ps patients before and after infliximab (IFX) treatment Between April 2007 and June 2009, 31 patients with active RA, PsA and Ps who were naïve to anti-TNF agents, were recruited from the Faculty Rheumatology Clinics at the University of Rochester Medical Center after informe

ORGANISM(S): Homo sapiens

SUBMITTER: Christopher Ritchlin 

PROVIDER: E-GEOD-57383 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress