Genomic profiling of DNA methyltransferases reveals a role for DNMT3B in genic methylation

ABSTRACT: DNA methylation is an epigenetic modification associated with transcriptional repression of promoters and is essential for mammalian development. Establishment of DNA methylation is mediated by the de novo DNA methyltransferases DNMT3A and DNMT3B, whereas DNMT1 ensures maintenance of methylation through replication. Absence of these enzymes is lethal, and somatic mutations in these genes have been associated with several human diseases. How genomic DNA methylation patterns are regulated remains poorly understood, as the mechanisms that guide recruitment and activity of DNMTs in vivo are largely unknown. To gain insights into this matter we determined chromosomal binding and site-specific activity of the mammalian de novo DNA methyltransferases DNMT3A and DNMT3B. We show that both enzymes l

ORGANISM(S): Mus musculus

SUBMITTER: Dirk Schuebeler 

PROVIDER: E-GEOD-57412 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress