APOBEC3B facilitates a functional and necessary link between estrogen receptor mediated transcription and DNA repair

ABSTRACT: Oestrogen receptor-α (ER) is the principal transcription factor in the majority of breast cancers, driving expression of genes that control cell growth and endocrine response. Understanding the mechanisms of ER action is crucial for improving response to endocrine treatments. Recent studies show that cytosine deaminase (CD) activity is an important source of cancer mutations. In particular, APOBEC3B (A3B) promotes mutagenesis in breast cancer cells1. Our analysis of breast cancer expression datasets showed that A3B expression predicts for poor survival in ER-positive, but not in ER-negative patients, indicative of a link with ER activity. Chromatin immunoprecipitation coupled to deep sequencing (ChIP-seq) used to map global A3B binding sites showed a remarkable oestrogen-stimulated recruit

ORGANISM(S): Homo sapiens

SUBMITTER: Luca Magnani 

PROVIDER: E-GEOD-57426 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress