Whole-genome microarray analysis was performed on cells treated with 5 μM dTAT for 1h
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ABSTRACT: Analysis of the impacto of dTAT treatment on primary human dermal flibroblast at the gene expression level. Results show that dTAT cytosolic penetration has a minimal impact on mRNA expression and that cells rapidly recover from treatment with dTAT. Primary Human dermal Fibroblast (HDF) were treated with dTAT (5µM) for 1h. Total RNA was harvested from HDF cells immediately, 1h or 24h after treatment.
Project description:Analysis of the impacto of dTAT treatment on primary human dermal flibroblast at the gene expression level. Results show that dTAT cytosolic penetration has a minimal impact on mRNA expression and that cells rapidly recover from treatment with dTAT.
Project description:Analysis of the impact of D-dTAT treatment on primary human dermal flibroblast (HDF) and immortalized fibroblast cells (MCH58) at the transcriptome level. Results show that D-dTAT cytosolic penetration dysregulation of mRNA expression compared to dfTAT treated and untreated cells.
Project description:miRNA profiling of human H9-derived neural stem cells (H9-NSCs) comparing control human adult dermal fibroblasts (hDFs), SOX2-transduced human induced neural stem cells (hDF-iNSC (SOX2)), SOX2/HMGA2-transduced human induced neural stem cells (hDF-iNSC (SOX2/HMGA2)). Goal was to determine the global miRNA expression between the groups. H9-NSC vs hDF vs hDF-iNSC(SOX2) vs hDF-iNSC(SOX2/HMGA2)
Project description:Detection of senescence-associated miRNAs differentially transcribed during early (D7) and late stages (D21) of human dermal fibroblast (HDF) senescence