Comparative phenotypic analysis of the major fungal pathogens Candida parapsilosis and Candida albicans

ABSTRACT: Abstract: Candida parapsilosis and Candida albicans are human fungal pathogens that belong to the CUG clade in the Saccharomycotina. In contrast to C. albicans, relatively little is known about the virulence properties of C. parapsilosis, a pathogen particularly associated with infections of premature neonates. We describe here the construction of >200 C. parapsilosis strains carrying double allele deletions of transcription factors, protein kinases and species-specific genes. Two independent deletions were constructed for each target gene. Growth in > 40 conditions was tested, including carbon source, temperature, and the presence of antifungal drugs. The phenotypes were compared to C. albicans strains with deletions of orthologous transcription factors. We found that many phenotypes ar

ORGANISM(S): Candida parapsilosis

SUBMITTER: Markus Schröder 

PROVIDER: E-GEOD-57451 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress