Direct genesis of functional rodent and human Schwann cells from skin mesenchymal precursors (rat)

ABSTRACT: Recent reports of directed reprogramming have raised questions about the stability of cell lineages. Here, we have addressed this issue, focusing upon skin-derived precursors (SKPs), a dermally-derived precursor cell. We show by lineage tracing that murine SKPs from dorsal skin originate from mesenchymal and not neural crest-derived cells. These mesenchymally-derived SKPs can, without genetic manipulation, generate functional Schwann cells, a neural crest cell type, and are highly similar at the transcriptional level to Schwann cells isolated from the peripheral nerve. This is not a mouse-specific phenomenon, since human SKPs that are highly similar at the transcriptome level can be made from facial (neural crest-derived) and foreskin (mesodermally-derived) dermis, and the mesodermally

ORGANISM(S): Rattus norvegicus

SUBMITTER: Freda Miller 

PROVIDER: E-GEOD-57505 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress