Detecting differential peaks in ChIP-seq signals with ODIN

ABSTRACT: Motivation: Detection of changes in DNA-protein interactions from ChIP-seq data is a crucial step in unraveling the regulatory networks behind biological processes. The simplest variation of this problem is the differential peak calling problem. Here one has to find genomic regions with ChIP-seq signal changes between two cellular conditions in the interaction of a protein with DNA. The great majority of peak calling methods can only analyse one ChIP-seq signal at a time and are unable to perform differential peak calling. Recently, a few approaches based on the combination of these peak callers with statistical tests for detecting differential digital expression have been proposed. However, these methods fail to detect detailed changes of protein-DNA interactions. Results: We propose ODIN

ORGANISM(S): Mus musculus

SUBMITTER: Martin Zenke 

PROVIDER: E-GEOD-57563 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress