Identification of Novel Post-Transcriptional Features in Olfactory Receptor Family mRNAs

ABSTRACT: Olfactory receptor (Olfr) genes comprise the largest gene family in mice. Despite their importance, most Olfr mRNAs are uncharacterized. Using RNA-seq analysis, we annotated the repertoire of mouse Olfr mRNAs expressed in the olfactory epithelium and found that they have several atypical features suggesting how post-transcriptional regulation impacts their expression. First, many Olfr mRNAs are intronless and those with introns typically have a single intron at the 5’ end. Second, Olfr mRNAs, as a group, have dramatically higher average AU content and lower predicted secondary structure than do control mRNAs. Third, Olfr mRNAs have a higher density of AU-rich elements (AREs) than control mRNAs. Fourth, Olfr mRNAs have much shorter 3’ UTR regions and fewer predicted binding sites for

ORGANISM(S): Mus musculus

SUBMITTER: Miles Wilkinson 

PROVIDER: E-GEOD-57567 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress