Unknown,Transcriptomics,Genomics,Proteomics

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Effects of (-)-cannabidiol on human sebocytes

ABSTRACT: In the current study, we aimed at exploring the effects of the major non-psychotropic phytocannabinoid of Cannabis sativa, (-)-cannabidiol (CBD), on human sebaceous gland functions. We found that CBD behaved as a highly effective anti-acne agent, targeting all the three key, sebocyte-specific steps of the pathogenesis (i.e. without compromising viability or basal sebaceous lipid production, CBD normalized pro-acne agents-induced excessive lipid synthesis, reduced proliferation and exerted anti-inflammatory actions). The goal of the present microarray analyses was to identify signaling pathways and target genes being involved in mediating the above beneficial effects of CBD. Microarray analyses were performed by using three independent sets of control (vehicle-treated) and CBD-treated (10 M-NM-

ORGANISM(S): Homo sapiens

SUBMITTER: Attila OlM-CM-!h

PROVIDER: E-GEOD-57571 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes.

Oláh Attila A Tóth Balázs I BI Borbíró István I Sugawara Koji K Szöllõsi Attila G AG Czifra Gabriella G Pál Balázs B Ambrus Lídia L Kloepper Jennifer J Camera Emanuela E Ludovici Matteo M Picardo Mauro M Voets Thomas T Zouboulis Christos C CC Paus Ralf R Bíró Tamás T

The Journal of clinical investigation 20140725 9

The endocannabinoid system (ECS) regulates multiple physiological processes, including cutaneous cell growth and differentiation. Here, we explored the effects of the major nonpsychotropic phytocannabinoid of Cannabis sativa, (-)-cannabidiol (CBD), on human sebaceous gland function and determined that CBD behaves as a highly effective sebostatic agent. Administration of CBD to cultured human sebocytes and human skin organ culture inhibited the lipogenic actions of various compounds, including ar ...[more]

PMID: 25061872

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Dataset Information

Effects of (-)-cannabidiol on human sebocytes

Publications

Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes.

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