Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Gene expression data from mouse hemopoietic stem cells (LSKs), promyelocytes, myelocytes and granulocytes.

ABSTRACT: Differentiation of hemopoietic stem cells into granulocytes is characterized by distinct changes in the transcriptome. We analyzed mRNA expression in primary murine myeloid cells at four successive stages of hemopoietic differentiation; Lin- Sca1+ cKit+ stem/progenitor cells (LSKs), promyelocytes, myelocytes and granulocytes. Using fluorescence–activated cell sorting, we isolated primary murine myeloid cells at four successive stages of hemopoietic differentiation; Lin- Sca1+ cKit+ stem/progenitor cells (LSK), promyelocytes, myelocytes and granulocytes.

ORGANISM(S): Mus musculus

SUBMITTER: Justin Wong 

PROVIDER: E-GEOD-57622 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Identification of nuclear-enriched miRNAs during mouse granulopoiesis.

Wong Justin J L JJ   Ritchie William W   Gao Dadi D   Lau Katherine A KA   Gonzalez Maria M   Choudhary Anupma A   Taft Ryan J RJ   Rasko John E J JE   Holst Jeff J  

Journal of hematology & oncology 20140515

<h4>Background</h4>MicroRNAs (miRNAs) are coordinators of cellular differentiation, including granulopoiesis. Although differential expression of many miRNAs is associated with the maturation of granulocytes, analysis of differentially expressed miRNAs and their cellular localization across all stages of granulopoiesis, starting from hemopoietic stems cells, is not well characterized.<h4>Methods</h4>We analyzed whole cell miRNA and mRNA expression during granulopoiesis using Taqman low-density a  ...[more]

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