Identification and characterization of retinoic acid-responsive genes in mouse kidney development

ABSTRACT: Retinoic acid (RA) signaling regulates a variety of developmental processes through controlling the expression of numerous genes. Here, we have identified and characterized RA-responsive genes in mouse kidney development. Analysis of isolated embryonic kidneys cultured in the presence and absence of RA identified 33 candidates of RA-responsive genes. Most of these candidate genes were down-regulated by treatment with the RA receptor antagonist. Many of them have potential binding sites for Elf5, one of the RA-responsive genes, in their promoter region. Whole-mount in situ hybridization demonstrated that specific expression of Elf5 in the ureteric trunk depends on RA. RA-dependent expression in the ureteric trunk was also demonstrated for the sodium channel subunit Scnn1b, which has been sh

ORGANISM(S): Mus musculus

SUBMITTER: Eisuke Nishida 

PROVIDER: E-GEOD-57656 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress