Alterations in circulating miRNAs following early-stage breast cancer resection

ABSTRACT: Introduction: Circulating microRNAs (miRNAs) exhibit remarkable stability and may serve as biomarkers in several clinical cancer settings. The aim of this study was to investigate changes in the levels of specific circulating miRNA following breast cancer surgery and evaluate whether these alterations were also observed in an independent data set. Methods: Global miRNA analysis was performed on prospectively collected serum samples from 24 post-menopausal women with estrogen receptor-positive early-stage breast cancer before surgery and 3 weeks after tumor resection using global LNA-based quantitative real-time PCR (qPCR). Results: Numbers of specific miRNAs detected in the samples ranged from 142 to 161, with 107 miRNAs detectable in all samples. After correction for multiple compariso

ORGANISM(S): Homo sapiens

SUBMITTER: Annette Kodahl 

PROVIDER: E-GEOD-57661 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress