The exon junction complex controls transposable element activity by ensuring the faithful splicing of the piwi transcript

ABSTRACT: The exon junction complex (EJC) is a highly conserved ribonucleoprotein complex which binds RNAs at a late stage of the splicing reaction and remains associated following export to the cytoplasm. This complex is involved in several cellular post-transcriptional processes including mRNA localization, translation and degradation. The EJC plays an additional role in the splicing of a subset of genes in Drosophila and in human cells but the underlying mechanism remains to be elucidated. Here, we have found a novel function for the EJC and its splicing subunit RnpS1 in preventing transposon accumulation in both Drosophila germline and surrounding follicular cells. This function is mediated specifically through the control of the splicing of the piwi transcript. In absence of RnpS1 one of the pi

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Jean-Yves Roignant 

PROVIDER: E-GEOD-57710 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress