A regulatory CD9+ B cell subset controls HDM-induced allergic airway inflammation

ABSTRACT: Background: A specific subset of regulatory IL-10 producing B cells has been extensively studied in autoimmune and inflammatory pathologies. These cells are able to constrain exacerbated inflammation by inhibiting T cell mediated responses and maturation of antigen presenting cells. In allergic diseases, observations that increase of regulatory B cells is necessary for allergen tolerance suggest that development of allergic asthma would be associated with a defect in the regulatory B cells compartment. Objective: We sought to (i) characterize regulatory IL-10+ regulatory B cell subset in Balb/c mice by microarray and flow cytometry and (ii) investigate their regulatory capacity in vivo in a house dust mite model of allergic asthma. Results: We identified an IL-10 producing B cells subset a

ORGANISM(S): Mus musculus

SUBMITTER: Faouzi Braza 

PROVIDER: E-GEOD-57772 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress