Gene Expression Signature in Adipose Tissue of Acromegaly Patients

ABSTRACT: OBJECTIVE: Acromegaly is a rare endocrine disorder with excess growth hormone (GH) production. This disorder has important metabolic effects in insulin resistance and lipolysis. The objective of this study was to explore transcriptional changes induced by GH in adipose tissue. METHODS: The patients underwent clinical and metabolic profiling including assessment of HOMA-IR. Explants of adipose tissue were assayed ex-vivo for lipolysis and ceramide levels. Adipose tissue was analyzed by RNA sequencing (RNA-seq). RESULTS: There was evidence of reduced insulin sensitivity based on the increase in fasting glucose, insulin and HOMA-IR score. We observed several previously reported transcriptional changes (IGF1, IGFBP3) as well as several novel transcriptional changes, some of which may be import

ORGANISM(S): Homo sapiens

SUBMITTER: Quynh Tran 

PROVIDER: E-GEOD-57803 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress