Transcriptomic effects of GLUT2 knock-down in zebrafish embryos

ABSTRACT: Glucose transporter 2 (GLUT2) is a key player in the regulation of glucose dynamics in organs central to metabolism, namely the liver, pancreas and intestine In humans, mutations of the GLUT2 gene (Fanconi-Bickel syndrome) cause important defects in glucose homeostasis. Although GLUT2 has been studied in the context of its participation in peripheral and central glucose sensing, to date it is still unclear which role it plays in the brain. In this regard, in order to shed some light on the function of GLUT2 in the vertebrate brain, we have knocked down the functional ortholog of human GLUT2 in zebrafish. Our results show that abrogation of glut2 in vivo leads to defective brain organogenesis coinciding with reduced glucose uptake and increased programmed cell death in the brain region. Int

ORGANISM(S): Danio rerio

SUBMITTER: Josep Planas 

PROVIDER: E-GEOD-57836 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress