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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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ETV5 transcription program links BDNF and promotion of EMT at invasive front of endometrial carcinomas.

ABSTRACT: We have characterized the transcriptional program regulated by ETV5 at the invasive front of endometrial carcinomas, by comparing it with non-invasive areas of the same tumor samples. In total 12 samples; 6 superficial (non-invasive) tumor areas and the corresponding invasive tumor zones.

ORGANISM(S): Homo sapiens

SUBMITTER: Miguel Abal

PROVIDER: E-GEOD-57870 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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ETV5 transcription program links BDNF and promotion of EMT at invasive front of endometrial carcinomas.

Alonso-Alconada Lorena L Eritja Nuria N Muinelo-Romay Laura L Barbazan Jorge J Lopez-Lopez Rafael R Matias-Guiu Xavier X Gil-Moreno Antonio A Dolcet Xavier X Abal Miguel M

Carcinogenesis 20140918 12

Myometrial infiltration represents a main clinical determinant of endometrial carcinomas (EC) presenting as aggressive high-grade deeply invasive neoplasms, substantially associated with risk of recurrence and death. The up-regulation of ETV5 transcription factor linked to the promotion of epithelial to mesenchymal transition is considered as a basic mechanism underlying the initial steps of EC invasion. In this work, we aimed to investigate the transcription program of tumor invasion regulated ...[more]

PMID: 25233929

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ETV5 transcription program links BDNF and promotion of EMT at invasive front of endometrial carcinomas.

Project description:We have characterized the transcriptional program regulated by ETV5 at the invasive front of endometrial carcinomas, by comparing it with non-invasive areas of the same tumor samples.

2014-11-05 | GSE57870 | GEO

Characterizing the invasive tumor front of aggressive uterine adenocarcinoma and leiomyosarcoma

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Expression data from cells located at the invasive front and in the tumor mass of mouse cervical squamous cell carcinomas

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Genome wide analysis of bivalent domains in two HUES cell lines

Project description:Human embryonic stem (HUES) cells are derived from early individual embryos with unique genetic properties. However, how their epigenetic status might affect their potential to differentiate toward specific lineages remains a puzzling question. Using ChIP-on-chip, the status of bivalent domains on gene promoters (i.e. H3K4 and H3K27 trimethylation) was monitored for both undifferentiated and BMP2 induced cardiac committed cells. A marked difference in the epigenetic profile of HUES cell lines was observed and this was correlated to the pattern of gene expression induced by BMP2 as well as to their potential to generate cardiac progenitors and differentiated myocytes. Thus, the epigenetic H3trimeK4 and H3trimeK27 prints generating bivalent domains on promoters, could be used to predict a preference in their differentiation toward a specific lineage. Using ChIP-on-chip, the status of bivalent domains on gene promoters (i.e. H3K4 and H3K27 trimethylation) was monitored for both undifferentiated and BMP2 induced cardiac committed cells.

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Deregulated MicroRNAs in Cancer-Associated Fibroblasts from Front Tumor Tissues of Lung Adenocarcinoma as Potential Predictors of Tumor Promotion

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Whole transcriptome assay of human urinary bladder cancer tumor samples from the central part and invasive front of individual tumors

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Genome-wide DNA methylation analysis on testicular embryonal carcinoma

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Project description:Characterizing the invasive tumor front of aggressive uterine adenocarcinoma and leiomyosarcoma

| PRJNA718540 | ENA