Enhancer-core promoter specificity separates developmental and housekeeping regulation

ABSTRACT: Gene transcription in animals involves the assembly of the RNA polymerase II complex at core promoters and its cell type-specific activation by genomic enhancers that can be located more distally. However, how ubiquitous expression of housekeeping genes is achieved has remained less clear. In particular, it is unknown whether ubiquitously active enhancers exist and how developmental and housekeeping gene regulation is separated. An attractive hypothesis is that different types of core promoters might exhibit an intrinsic specificity towards certain types of enhancers. Here, we show that thousands of enhancers in D. melanogaster S2 cells and ovarian somatic cells (OSCs) exhibit a marked specificity towards one of two core promoters M-bM-^@M-^S one derived from a ubiquitously expressed ribos

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Alexander Stark 

PROVIDER: E-GEOD-57876 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress