Resistance to aerobic exercise training causes metabolic dysfunction and reveals novel exercise-regulated signaling networks

ABSTRACT: Low aerobic exercise capacity is a risk factor for diabetes and strong predictor of mortality; yet some individuals are exercise resistant, and unable to improve exercise capacity through exercise training. To test the hypothesis that resistance to aerobic exercise training underlies metabolic disease-risk, we used selective breeding for 15 generation to develop rat models of low- and high-aerobic response to training. Before exercise training, rats selected as low- and high-responders had similar exercise capacities. However, after 8-wks of treadmill training low-responders failed to improve their exercise capacity, while high-responders improved by 54%. Remarkably, low-responders to aerobic training exhibited pronounced metabolic dysfunction characterized by insulin resistance and increa

ORGANISM(S): Rattus norvegicus

SUBMITTER: Iain Gallagher 

PROVIDER: E-GEOD-57880 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress