Gene expression analysis of tumorigenic versus non-tumorigenic canine osteosarcoma cell lines

ABSTRACT: An increased serum alkaline phosphatase concentration is known to be associated with a negative prognosis in canine and human osteosarcoma. To expand upon previous studies regarding the biological relevance of increased serum alkaline phosphatase as a negative prognostic factor, xenogeneic heterotopic transplants were performed using six canine primary osteosarcoma cell lines generated from patients with differing serum alkaline phosphatase concentrations (3 normal and 3 increased). Three of the six cell lines were capable of generating tumors and tumor formation was independent of the serum alkaline phosphatase status of the cell line. Microarray analysis identified 379 genes as being differentially-expressed between the tumorigenic and non-tumorigenic cell lines. Frizzled-6 was up-re

ORGANISM(S): Canis lupus familiaris

SUBMITTER: Timothy Stein 

PROVIDER: E-GEOD-57884 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress