White-to-brown metabolic conversion of human adipocytes by JAK inhibition

ABSTRACT: The rising incidence of obesity and related disorders such as diabetes and heart disease has focused considerable attention on the discovery of novel therapeutics. One promising approach has been to increase the number or activity of brown-like adipocytes in white adipose depots, as this has been shown to prevent diet-induced obesity and reduce the incidence and severity of type 2 diabetes. Thus, the conversion of fat-storing cells into metabolically active thermogenic cells has become an appealing therapeutic strategy to combat obesity. Here, we report a screening platform for the identification of small molecules capable of promoting a white-to-brown metabolic conversion in human adipocytes. We identified two inhibitors of Janus Kinase (JAK) activity with no precedent in adipose

ORGANISM(S): Homo sapiens

SUBMITTER: Jitao David Zhang 

PROVIDER: E-GEOD-57896 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress