MMSET Induces Global and Focal Changes in Histone Methylation in Myeloma Cells

ABSTRACT: We investigated genome wide distribution of H3K36me2, H3K36me3 and H3K27me3 in the presence and absence of MMSET protein. MMSET overexpression in t(4;14)+ myeloma leads to global loss redistribution of H3K36me2 and genome-wide loss of H3K27 methylation. Despite the gloal decrease in H3K27me3, specific regions of the genome show enhanced H3K27me3 enrichment through increased recruitment of EZH2 methyltransferase ChIP-seq for H3K36me2, H3K36me3 and H3K27me3 in two cell types

ORGANISM(S): Homo sapiens

SUBMITTER: Relja Popovic 

PROVIDER: E-GEOD-57977 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress