The immediate global responses of Aliivibrio salmonicida to iron limitations

ABSTRACT: Iron is an essential micronutrient for all living organisms, and sequestering of iron and the virulence of pathogenic bacteria are believed to be correlated. As the defense mechanisms, potential hosts therefore keep the level of free iron inside the body to a minimum. The iron metabolism is well studied in general for several pathogens of humans and animals, but it is still mostly unclear how gene expression levels change in pathogens during the initial stages of infections. In this work, using Aliivibrio salmonicida we studied the immediate changes in transcription levels in response to a sudden decrease in iron levels. Microarray technology was used to monitor global changes in transcriptional levels. Cultures of A. salmonicida were grown to mid log phase before the iron chelator 2,2M-bM

ORGANISM(S): Aliivibrio salmonicida LFI1238

SUBMITTER: Espen Robertsen 

PROVIDER: E-GEOD-57996 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress