Ovarian gene expression in the absence of FIGLA, an oocyte specific transcription factor

ABSTRACT: Ovarian folliculogenesis in mammals is a complex process involving cross talk between germ and somatic cells. Carefully orchestrated expression of transcription factors, cell adhesion molecules and growth factors are required for success. We have identified a germ-cell specific, basic helix-loop-helix transcription factor, FIGLA (Factor In the GermLine, Alpha) and demonstrated its involvement in two independent developmental processes: formation of the primordial follicle and coordinate expression of zona pellucida genes. Taking advantage of Figla null mouse lines, we have used a combined approach of microarray and Serial Analysis of Gene Expression (SAGE) to identify potential downstream targets genes. Using high stringent cutoffs, we find that FIGLA functions as a key regulatory molecule

ORGANISM(S): Mus musculus

SUBMITTER: saurabh joshi 

PROVIDER: E-GEOD-5802 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress