A high resolution map of segmental DNA copy number variation in the mouse genome

ABSTRACT: Submicroscopic (< 2 Mb) segmental DNA copy number changes are a recently recognized source of genetic variability between individuals. The biological consequences of copy number variants (CNVs) are largely undefined. CNVs have been detected in diverse species, including mice and humans. Published studies in mice have been limited by resolution and strain selection. We chose to study twenty-one well-characterized inbred mouse strains that are the focus of an international effort to measure, catalog, and disseminate phenotype data. We performed comparative genomic hybridization using long oligomer arrays (oligo-aCGH) to characterize CNVs in these strains. This technique increased the resolution of CNV detection by more than an order of magnitude over previous methodologies. The CNVs ra

ORGANISM(S): Mus musculus

SUBMITTER: Patrick Cahan 

PROVIDER: E-GEOD-5805 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress