Sox4 links tumor suppression to accelerated aging in mice [Telogen]

ABSTRACT: Sox4 is a transcription factor expressed during embryonic development and some adult tissues such as lymphoid organs, pancreas, intestine and skin. During embryogenesis, Sox4 regulates the survival of mesenchymal and neural progenitors, lymphocyte and myeloid differentiation, and pancreatic, bone and cardiac development. Aberrantly increased Sox4 expression is linked to malignant transformation and metastasis in several types of human cancer. To study the role of Sox4 in the adult organism, we first generated mice with reduced whole-body Sox4 expression. These mice display a plethora of age-related degenerative disorders and reduced spontaneous cancer incidence, indicating a role for this protein in maintaining adult tissue homeostasis and in tumor growth. To specifically address a role fo

ORGANISM(S): Mus musculus

SUBMITTER: Miguel Foronda 

PROVIDER: E-GEOD-58154 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress