Sox4 links tumor suppression to accelerated aging in mice
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Miguel Foronda
PROVIDER: E-GEOD-58155 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Sox4 links tumor suppression to accelerated aging in mice by modulating stem cell activation.
Foronda Miguel M Martínez Paula P Schoeftner Stefan S Gómez-López Gonzalo G Schneider Ralph R Flores Juana M JM Pisano David G DG Blasco Maria A MA
Cell reports 20140717 2
Sox4 expression is restricted in mammals to embryonic structures and some adult tissues, such as lymphoid organs, pancreas, intestine, and skin. During embryogenesis, Sox4 regulates mesenchymal and neural progenitor survival, as well as lymphocyte and myeloid differentiation, and contributes to pancreas, bone, and heart development. Aberrant Sox4 expression is linked to malignant transformation and metastasis in several types of cancer. To understand the role of Sox4 in the adult organism, we fi ...[more]
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