Transcription profiling of lung cancer cells treated with 5-aza - a genome-wide screen for hypermethylated genes in lung cancer

ABSTRACT: Abstract; Background: Promoter hypermethylation coupled with loss of heterozygosity at the same locus results in loss of gene function in many tumor cells. The “rules” governing which genes are methylated during the pathogenesis of individual cancers, how specific methylation profiles are initially established, or what determines tumor-type specific methylation are unknown. However, DNA methylation markers that are highly specific and sensitive for common tumors would be useful for the early detection of cancer, and those required for the malignant phenotype identify pathways important as therapeutic targets. Methods and Findings: In an effort to identify new cancer-specific methylation markers, we employed a high throughput global expression profiling approach in lung cancer cell

ORGANISM(S): Homo sapiens

SUBMITTER: David Shames 

PROVIDER: E-GEOD-5816 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress