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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Comparison of the Streptococcus pneumoniae D39 lacR Mutant compared to D39 wild-type

ABSTRACT: Comparison of the Streptococcus pneumoniae D39 lacR mutant compared to D39 wild type in M17 medium+ 0.5 % (w/v) Glucose (GM17) Two condition design comparison of Wild-type strain including a dye swap

ORGANISM(S): Streptococcus pneumoniae D39

SUBMITTER: Sulman Shafeeq

PROVIDER: E-GEOD-58183 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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LacR is a repressor of lacABCD and LacT is an activator of lacTFEG, constituting the lac gene cluster in Streptococcus pneumoniae.

Afzal Muhammad M Afzal Muhammad M Shafeeq Sulman S Kuipers Oscar P OP

Applied and environmental microbiology 20140620 17

Comparison of the transcriptome of Streptococcus pneumoniae strain D39 grown in the presence of either lactose or galactose with that of the strain grown in the presence of glucose revealed the elevated expression of various genes and operons, including the lac gene cluster, which is organized into two operons, i.e., lac operon I (lacABCD) and lac operon II (lacTFEG). Deletion of the DeoR family transcriptional regulator lacR that is present downstream of the lac gene cluster revealed elevated e ...[more]

PMID: 24951784

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