Transcription profiling of tolerizing murine cardiac allograft to understand the precise mechanisms of immunological tolerance.

ABSTRACT: C57/BL6 to C57/BL6; Balb/c to C57/BL6; Balb/c to C57/BL6 with anti CD80/86 mAb; Identificaton of gene expression profile in tolerizing murine cardiac allograft by co-stimulatory blockade. The induction of specific tolerance would be the ultimate achievement in transplant immunology, but the precise mechanisms of immunological tolerance remain largely unknown. Here, we investigated global gene expression analysis in tolerizing murine cardiac allografts by means of oligonucleotide microarrays. Tolerance induction was achieved in cardiac allografts from BALB/c to C57BL/6 mice by daily intraperitoneal injection of anti-CD80 and CD86 mAbs. Comparative analysis revealed 64 genes to be induced more extensively in the tolerizing than in the syngeneic isografts, and 16 genes than in the rejecting a

ORGANISM(S): Mus musculus

SUBMITTER: Yuichi Matsui 

PROVIDER: E-GEOD-582 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress