Pontin functions as an essential coactivator for Oct4 target genes and lincRNAs in embryonic stem cells.

ABSTRACT: The actions of transcription factors, chromatin modifiers, and noncoding RNAs are crucial for the programming of cellular states. Although chromatin remodeling factors regulate the functional status of cells including pluripotency and differentiation, how they cross-talk with embryonic stem (ES) cell-specific transcription factors and noncoding RNAs to coordinate networks controlling of ES cell identity remain unknown. Here, we find that Pontin chromatin remodeling factor plays an essential role as a coactivator for Oct4 target genes and large intergenic noncoding RNAs (lincRNAs) in ES cells. mRNA- and ChIP-sequencing analyses reveal that Pontin and Oct4 share a substantial set of target genes involved in maintenance of ES cells. Intriguingly, Oct4-dependent coactivator function of Pont

ORGANISM(S): Mus musculus

SUBMITTER: Bhin Jin-hyuk 

PROVIDER: E-GEOD-58206 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress